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M94A3190.TXT
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1994-10-25
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Document 3190
DOCN M94A3190
TI Maintenance of high virus load even after seroconversion in newborn cats
acutely infected with feline immunodeficiency virus.
DT 9412
AU Zheng YH; Tokunaga K; Shoda K; Nishino Y; Kishi M; Zhong Q; Asahi S;
Ishihara C; Kanda M; Ikuta K; Inst. Immunol. Sci., Hokkaido Univ.,
Sapporo, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):132 (abstract no. PA0149). Unique
Identifier : AIDSLINE ICA10/94369385
AB OBJECTIVE: As an animal model for HIV pediatric infection, we examined
whether or not the time at which viral infection occurs is an important
factor for FIV-induced pathogenesis. METHODS: Three newborn and two
adult cats were intraperitoneally inoculated with FIV Petaluma
strain-infected feline T-lymphoblastoid cells. Virus load and antibody
response were kinetically compared between the infected newborn and
adult cats. RESULTS: The virus genome number in peripheral blood
mononuclear cells (PBMC) was progressively increased even after
seroconversion in the infected newborn cats, whereas followed rapidly by
apparent virus genome clearance after seroconversion in the infected
adult cats. In addition, all the infected newborn cats developed
symptom, such as respiratory disease and stomatitis, about two months
after the infection. The co-cultures of PBMC with T cells showed that
FIV in newborn cats were cytopathic even after seroconversion, whereas
FIV in adult cats converted from cytopathic to less cytopathic phenotype
after seroconversion. DISCUSSION AND CONCLUSION: FIV infection in
newborn cats maintained high virus load with pathogenic potential,
leading to rapid development of the disease. This might be due to T cell
specific immunotolerance or T cell dysfunction.
DE Animal Animals, Newborn Cats Cells, Cultured Feline Acquired
Immunodeficiency Syndrome/IMMUNOLOGY/ *PHYSIOPATHOLOGY Genome, Viral
Immune Tolerance Immunodeficiency Virus, Feline/GENETICS/ISOLATION &
PURIF/ *PHYSIOLOGY Lymphocytes/IMMUNOLOGY/MICROBIOLOGY
T-Lymphocytes/IMMUNOLOGY Time Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).